Point: Exercise training-induced bradycardia is caused by changes in intrinsic sinus node function.
نویسندگان
چکیده
in intrinsic sinus node function 5 6 7 Mark R. Boyett, Yanwen Wang, Shu Nakao, Jonathan Ariyaratnam, George Hart, 8 Oliver Monfredi and Alicia D’Souza 9 10 11 Cardiovascular Sciences, University of Manchester, UK 12 13 14 Corresponding author: Professor Mark Boyett, Cardiovascular Sciences, University of Manchester, 15 46 Grafton Street, Manchester M13 9NT, UK 16 Phone: +44-161-2751192 Email: [email protected] 17 18 Articles in PresS. J Appl Physiol (July 6, 2017). doi:10.1152/japplphysiol.00604.2017
منابع مشابه
Exercise training reduces resting heart rate via downregulation of the funny channel HCN4
Endurance athletes exhibit sinus bradycardia, that is a slow resting heart rate, associated with a higher incidence of sinus node (pacemaker) disease and electronic pacemaker implantation. Here we show that training-induced bradycardia is not a consequence of changes in the activity of the autonomic nervous system but is caused by intrinsic electrophysiological changes in the sinus node. We dem...
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RATIONALE Downregulation of the pacemaking ion channel, HCN4 (hyperpolarization-activated cyclic nucleotide gated channel 4), and the corresponding ionic current, If, underlies exercise training-induced sinus bradycardia in rodents. If this occurs in humans, it could explain the increased incidence of bradyarrhythmias in veteran athletes, and it will be important to understand the underlying pr...
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The mechanisms responsible for exercise-induced reductions in baseline heart rate (HR), known as training bradycardia, remain controversial. Therefore, changes in cardiac autonomic regulation and intrinsic sinoatrial nodal (SAN) rate were evaluated using dogs randomly assigned to either a 10- to 12-wk exercise training (Ex, n = 15) or an equivalent sedentary period (Sed, n = 10). Intrinsic HR w...
متن کاملRebuttal from Billman on Point:Counterpoint: Exercise training-induced bradycardia.
BOYETT AND COWORKERs (4) identified three potential weaknesses with the autonomic neural hypothesis: 1) the contribution of changes in heart rate (HR) to heart rate variability (HRV), 2) the HR response to atropine, and 3) training effects in cardiac transplant patients. The authors note that due to the inverse curvilinear relationship between HR and R-R interval (9), changes in HR per se can a...
متن کاملAthlete's bradycardia may be a multifactorial mechanism.
TO THE EDITOR: Boyett et al. (1) provides interesting evidences, arguing that endurance training-induced bradycardia seems mostly related to a remodeling of the sinoatrial node. However, we would like to add four complementary elements to extend this paper. About intrinsic heart rate. In Boyett et al.’s Table 1, seven studies explored long-time endurance athletes and three studies explored subj...
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ورودعنوان ژورنال:
- Journal of applied physiology
دوره شماره
صفحات -
تاریخ انتشار 2017